A POTENSI ANTIKOAGULAN EKSTRAK MENGKUDU ( MORINDA CITRIFOLIA L. ) DENGAN METODE LEE WHITE DAN APUSAN DARAH

ANTICOAGULANT POTENTIAL OF NORI EXTRACT (MORINDA CITRIFOLIA L.) USING THE LEE WHITE METHOD AND BLOOD SWAP

Abstract

Noni (Morinda citrifolia L.) is known to contain coumarin compounds which have the potential to act as anticoagulants to prevent blood clots. This study aims to test the anticoagulant potential of noni extract using the Lee White method and blood smears. This method was carried out on 15 blood samples to which noni extract was added at a concentration of 0.128 g and 0.192 g. Clotting time was measured using the Lee White method, while changes in blood morphology were observed through blood smears. The results showed that a concentration of 0.128 g of noni extract produced an average clotting time of 11 minutes 35 seconds, while at a concentration of 0.192 g the clotting time increased to an average of 14 minutes 37 seconds. Statistical tests showed that the increase in clotting time at both concentrations of noni extract was significant (p > 0.05), which supports the hypothesis that noni extract has an anticoagulant effect. In conclusion, noni extract has the potential as an anticoagulant agent that can prolong blood clotting time, so it has the potential to be used as an alternative natural anticoagulant for blood clotting therapy.